Human PLAGL1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PLAGL1
Locus ID	5325
Kit Components	GA103585G1, PLAGL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103585G2, PLAGL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103585G3, PLAGL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001080951, NM_001080952, NM_001080953, NM_001080954, NM_001080955, NM_001080956, NM_001289037, NM_001289038, NM_001289039, NM_001289040, NM_001289041, NM_001289042, NM_001289043, NM_001289044, NM_001289045, NM_001289046, NM_001289047, NM_001289048, NM_001289049, NM_001317156, NM_001317157, NM_001317158, NM_001317159, NM_001317160, NM_001317161, NM_001317162, NM_002656, NM_006718
Synonyms	LOT1; ZAC; ZAC1
Summary	This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]

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