Human ADAMTS13 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ADAMTS13
Locus ID	11093
Kit Components	GA107626G1, ADAMTS13 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107626G2, ADAMTS13 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107626G3, ADAMTS13 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_017587, NM_139025, NM_139026, NM_139027, NM_139028, NR_024514
Synonyms	ADAM-TS13; ADAMTS-13; C9orf8; vWF-CP; VWFCP
Summary	This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

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