Human CHREBP (MLXIPL) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MLXIPL
Locus ID	51085
Kit Components	GA109550G1, CHREBP gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109550G2, CHREBP gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109550G3, CHREBP gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_015977, NM_032951, NM_032952, NM_032953, NM_032954, NM_032994, NR_134541
Synonyms	bHLHd14; CHREBP; MIO; MLX; MONDOB; WBSCR14; WS-bHLH
Summary	This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

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