Human DC2L1 (DYNC2LI1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DYNC2LI1
Locus ID	51626
Kit Components	GA109908G1, DC2L1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109908G2, DC2L1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109908G3, DC2L1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001012665, NM_001193464, NM_015522, NM_016008, NM_001348912, NM_001348913
Synonyms	CGI-60; D2LIC; DKFZp564A033; dynein, cytoplasmic 2, light intermediate chain 1; dynein 2 light intermediate chain; LIC3
Summary	This gene encodes a protein that is a component of the dynein-2 microtubule motor protein complex that plays a role in the retrograde transport of cargo in primary cilia via the intraflagellar transport system. This gene is ubiquitously expressed and its protein, which localizes to the axoneme and Golgi apparatus, interacts directly with the cytoplasmic dynein 2 heavy chain 1 protein to form part of the multi-protein dynein-2 complex. Mutations in this gene produce defects in the dynein-2 complex which result in several types of ciliopathy including short-rib thoracic dysplasia 15 with polydactyly (SRTD15). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]

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