Human NPL4 (NPLOC4) activation kit by CRISPRa

CAT#: GA110868

NPLOC4 CRISPRa kit - CRISPR gene activation of human NPL4 homolog, ubiquitin recognition factor



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

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NPLOC4 Rabbit polyclonal Antibody
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Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol NPLOC4
Locus ID 55666
Kit Components

GA110868G1, NPL4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA110868G2, NPL4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA110868G3, NPL4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_017921, NR_130139, NR_130140, NM_001369698
Synonyms NPL4
Summary The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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