Mouse Srd5a3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Srd5a3
Locus ID	57357
Kit Components	GA206174G1, Srd5a3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206174G2, Srd5a3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206174G3, Srd5a3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_020611
Synonyms	1110025P14Rik; A430076C09; AV364670; AW987574; D730040M03Rik; H5ar; S5AR 3; Srd5a2l
Summary	Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).[UniProtKB/Swiss-Prot Function]

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