Mouse Sertad2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sertad2
Locus ID	58172
Kit Components	GA206247G1, Sertad2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206247G2, Sertad2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206247G3, Sertad2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001038625, NM_021372, NM_001362867
Synonyms	AB041541; AU021878; Kiaa0127; mKIAA0127; MNCb-1504; SEI-2; Sei2; TRIP-Br2
Summary	Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.[UniProtKB/Swiss-Prot Function]

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