Mouse Fbxo7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fbxo7
Locus ID	69754
Kit Components	GA208310G1, Fbxo7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208310G2, Fbxo7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208310G3, Fbxo7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001310745, NM_001347151, NM_153195
Synonyms	2410015K21Rik; A230052G17Rik; AI117679; AW260462; C85118
Summary	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity).[UniProtKB/Swiss-Prot Function]

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