Angiotensinogen (AGT) Mouse Monoclonal Antibody [Clone ID: 1B1]

Specifications

Product Data
Clone Name	1B1
Applications	ELISA, WB
Recommend Dilution	ELISA:  1/10000. Western Blot: 1/500 - 1/2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human AGT expressed in E. Coli.
Specificity	Recognizes  Angiotensinogen (AGT).
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	53 kDa
Gene Name	angiotensinogen
Database Link	Entrez Gene 183 Human UniProt ID P01019
Background	AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Synonyms	AGT, SERPINA8, Angiotensin I, Angiotensin II, Angiotensin III, Angiotensin IV, Angiotensin-1, Angiotensin-2, Angiotensin-3, Angiotensin-4
Reference Data

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