PDGF Receptor beta (PDGFRB) Mouse Monoclonal Antibody [Clone ID: 18A2]

Specifications

Product Data
Clone Name	18A2
Applications	FC, IF, IHC
Recommend Dilution	Flow Cytometry: 1-5 µg/ml. Immmunocytochemistry. Immunohistochemistry on Frozen Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	CD140b-transfected NIH 3T3 cells
Specificity	This antibody recognizes CD140b / PDGF-RB, the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.
Formulation	PBS, pH~7.4 State: Purified State: Liquid purified Ig fraction from Cell Culture Supernatant (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	platelet derived growth factor receptor beta
Database Link	Entrez Gene 5159 Human UniProt ID P09619
Background	CD140b / PDGF-RB (platelet-derived growth factor receptor beta) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a / PDGF-RA. Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumours such as medulloblastoma.
Synonyms	PDGF-R-beta, PDGF Receptor beta
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Protein Pathways	Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton

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