BPV-1 Protein E2 (310-410) Mouse Monoclonal Antibody [Clone ID: 5H4]

Specifications

Product Data
Clone Name	5H4
Applications	ELISA, FN, IF
Recommend Dilution	Immunoflourescence. ELISA. Functional application: specifically dissociates E2 protein from DNA (Kurg et al, 1999). This is a conformational antibody and does not work in Western immunoblotting analysis or in other denaturative conditions.
Reactivity	Bovine
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody detects Bovine Papillomavirus E2-protein, mapped to amino acids 310-410.
Formulation	PBS with 50% glycerol State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20 to -70 °C. Avoid repeated freezing and thawing.
Database Link	UniProt ID P03122
Background	The bovine papilloma virus E2 protein is the master regulator of papillomavirus replication and transcription. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
Synonyms	BPV1 Regulatory protein E2
Reference Data

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