CD44 Mouse Monoclonal Antibody [Clone ID: B-F24]

Specifications

Product Data
Clone Name	B-F24
Applications	ELISA, FC, FN, IP
Recommend Dilution	Immunoprecipitation. Flow Cytometry. Functional Assay: Triggers T Lymphocyte Aggregation. Enhances hyaluronan binding to CD44.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	U937 cell line
Specificity	Recognises the soluble Hyaluronate Cell Adhesion Molecule (H-CAM), a 85-250 kDa protein.
Formulation	Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free. State: Azide Free State: Liquid purfied Ig fraction.
Concentration	lot specific
Purification	Ion Exchange Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	CD44 molecule (Indian blood group)
Database Link	Entrez Gene 960 Human UniProt ID P16070
Background	CD44 is a type 1 transmembrane glycoprotein also known as Phagocytic Glycoprotein 1 (pgp 1) and HCAM. CD44 is the receptor for hyaluronate and exists as a large number of different isoforms due to alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells, and erythrocytes is a glycosylated type 1 transmembrane protein. Other isoforms contain glycosaminoglycans and are expressed on hematopoietic and non hematopoietic cells. CD44 is involved in adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix.
Synonyms	LHR, MDU2, MDU3, MIC4, CDw44, Epican, ECMR-III, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, PGP-1
Reference Data
Protein Families	Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transmembrane
Protein Pathways	ECM-receptor interaction, Hematopoietic cell lineage

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