Myeloid Lineage Mouse Monoclonal Antibody [Clone ID: OX-82]

Specifications

Product Data
Clone Name	OX-82
Applications	FC, IHC, WB
Recommend Dilution	Flow Cytometry. This clone OX-82 has been reported for use in Western Blotting and Immunohistochemistry on Frozen Sections (Ref. 2).
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Anemic Rat bone marrow.
Specificity	This Myeloid Lineage monoclonal antibody recognizes a 35 kDa antigen found on myeloid cells and stromal elements from a variety of tissues in the adult Rat.
Formulation	PBS containing 0.02% Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. Label: PE State: Liquid purified IgG fraction.
Purification	Protein G Chromatography of Ascites fluid.
Conjugation	PE
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Background	Hematopoietic stem cells (HSC) are the precursor cells found in the bone marrow which give rise to all the blood cell types of both the Myeloid and lymphoid lineages, which include monocytes and macrophages, neutrophils, basophils, eosinophils, T cells, B cells, NK cells, microglia, erythrocytes, megakaryocytes and dendritic cells. During the process of hematopoiesis, Myeloid lineage cells originate from the bone marrow, while Lymphoid lineage cells originate from the lymph tissue. Blimp-1 is a key regulator of the differentiation of the separate hematopoietic myeloid and lymphoid lineages. The distinction between myeloid and lymphoid lineages is essential to diagnose and treat certain cancers. Myeloid lineage cells induce inflammatory cytokine production upon activation by Kaposi's sarcoma-associated herpesvirus OX2 glycoprotein. At the stage of myelocytes, Myeloid lineage cells express a substantial number of IL-8 receptor homologs.
Reference Data

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