Protein C (PROC) Mouse Monoclonal Antibody [Clone ID: CaC-11]

Specifications

Product Data
Clone Name	CaC-11
Applications	ELISA, WB
Recommend Dilution	ELISA: 3.9 ng/ml Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human Protein C purified from the supernatant of thrombin activated platelets.
Specificity	This antibody is specific for Human Protein C/APC in the presence of 5-10 mM CaCl2.
Formulation	PBS containing 0.02% Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein C, inactivator of coagulation factors Va and VIIIa
Database Link	Entrez Gene 5624 Human UniProt ID P04070
Background	Protein C (PC) is a major physiological anticoagulant, and an important regulator of the blood coagulation system. PC is a vitamin K dependent serine protease enzyme that is activated by thrombin. The anticoagulant PC is converted to activated protein C (APC) by the thrombomodulin (TM) – thrombin complex on the phospholipid surface of endothelial cells, monocytes and platelets. APC degrades coagulation Factors Va and VIIIa rendering these factors inactive. APC provides physiologic antithrombotic activity and exhibits both anti-inflammatory and anti-apoptotic activity. Treatment with APC has been shown to improve the clinical outcome of patients with sepsis.
Synonyms	Vitamin K-dependent protein C, Anticoagulant protein C, PROC1, Autoprothrombin IIA, Blood coagulation factor XIV
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Complement and coagulation cascades

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