Estrogen Receptor 1 (ESR1) pSer104 Rabbit Polyclonal Antibody

CAT#: AP01581PU-N

Estrogen Receptor 1 (ESR1) pSer104 rabbit polyclonal antibody, Aff - Purified



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CNY 4,437.00


货期*
2周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution ELISA: 1/5000-1/10000.
Western Blot: 1/500-1/1000.
Immunohistochemistry: 1/50-1/200.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of Estrogen Receptor-alpha pSer104 protein.
Formulation Phosphate buffered saline (PBS), pH~7.2 containing 15 mM Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name estrogen receptor 1
Background Estrogen receptor α (ERα, ER, ESR, ESRA, Era, NR3A1, estrogen receptor 1) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding and activation of transcription. Alternative splicing results in several ERα mRNA transcripts, which differ primarily in their 5' untranslated regions. ERα undergoes phosphorylation in response to estradiol binding. Human ERα is predominately phosphorylated on Ser 118 and to a lesser extent on Ser 104 and Ser 106. In response to activation of the mitogen-activated protein kinase pathway, phosphorylation occurs on Ser 118 and Ser 167. These Serine residues are all located within the activation function 1 region of the N-terminal domain of ERα. In contrast, activation of protein kinase A increases the phosphorylation of Ser 236, which is located in the DNA-binding domain. Src kinase-dependent Tyr 537 phosphorylation may enhance estrogen binding to ERα. Mutation of Tyr 537 of the human ERα produces receptors having a range of constitutive activity.
Synonyms ER alpha, Estradiol receptor, ESR1, ESR, NR3A1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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