SGPL1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1/400.  Positive Control: Madin-Darby Bovine Kidney (MDBK) cell lysate.
Reactivity	Bovine, Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the sphingosine 1-phosphate lyase 1 protein.
Specificity	This antibody recognizes Sphingosine 1-Phosphate Lyase 1.
Formulation	PBS State: Aff - Purified State: Liquid purified IgG fraction Preservative: 0.08% Sodium Azide
Concentration	lot specific
Purification	Antigen Immunoaffiinity Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	sphingosine-1-phosphate lyase 1
Database Link	Entrez Gene 20397 MouseEntrez Gene 286896 RatEntrez Gene 8879 Human UniProt ID O95470
Background	Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1-phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.
Synonyms	SP-lyase 1, SPL 1, Sphingosine-1-phosphate aldolase, Sphingosine-1-phosphate lyase 1, KIAA1252
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Sphingolipid metabolism

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