CRM1 (XPO1) (390-408) Rabbit Polyclonal Antibody

CAT#: AP08259PU-N

CRM1 (XPO1) (390-408) rabbit polyclonal antibody, Aff - Purified



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CNY 5,511.00


货期*
5周

规格
    • 50 ug

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Western Blot: 1 - 3 µg/ml.
Reactivity Bovine, Canine, Human, Chimpanzee, Mouse, Rat, Bat, Chicken, Equine, Monkey, Xenopus
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to the amino acids 390-408 of human Exportin-1 protein
Specificity This antibody recognizes CRM1 Protein (XPO1) at aa 390-408.
Formulation PBS containing 0.05% Sodium Azide as preservative and 0.2% Gelatin as stabilizer
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Protein G Chromatography
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name exportin 1
Background CRM1 (chromosome region maintenance 1 protein homolog) mediates the nuclear export of cellular proteins (cargoes) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, CRM1 binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The direction of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. CRM1 also mediates the nuclear export of the Rev protein of HIV-1 and Rex protein of HTLV-1. It is involved in Rex dimerization, U3 snoRNA transport from Cajal bodies to nucleoli.
CRM1 is also involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. CRM1 is also involved in the regulation NFAT and AP-1.
Synonyms Exp1, CRM1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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