ALDH5A1 (485-496) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	Peptide ELISA: 1/32000 (Detection Limit).  Western blot: 0.3-1 µg/ml. This antibody detects a band of Approx 55kDa in Human Liver lysates and 50kDa band in Mouse and Rat Liver lysates. Immunohistochemistry on Paraffin Sections: 5-10 µg/ml. In paraffin embedded Human Liver shows heavy textured cystoplasm staining in hepatocytes, consistent with mitochondia.
Reactivity	Bovine, Canine, Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the internal region of Human ALDH5A1.
Specificity	This antibody is expected to recognize both reported isoforms (NP_733936.1; NP_001071.1).
Formulation	Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	aldehyde dehydrogenase 5 family member A1
Database Link	Entrez Gene 214579 MouseEntrez Gene 291133 RatEntrez Gene 7915 Human UniProt ID P51649
Background	Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.
Synonyms	SSADH; SSDH
Note	Calculated Molecular Weight: 58.7kDa (NP_733936.1).
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Alanine, aspartate and glutamate metabolism, Butanoate metabolism, Metabolic pathways

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