NF-kB p65 (RELA) pSer276 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA: 1:500,000 -1:2,000,000, detects the serine 276 phosphorylated NF-κB p65 peptide coated on ELISA plate.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from Serine 276 phosphorylated NF-κB p65, conjugated with KLH
Specificity	Detects Serine 276 phosphorylated NF-κB p65 on Mouse, Human and other species with consensus serine 276 phosphorylated NF-κB p65 peptide (QLRRPSpDRELS).
Formulation	0.01M PBS, pH 7.4 State: Azide Free State: Lyophilized Ig fraction
Reconstitution Method	Restore with double distilled water to adjust the final concentration to 1.00 mg/ml.
Purification	Protein G affinity purified
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	RELA proto-oncogene, NF-kB subunit
Database Link	Entrez Gene 5970 Human UniProt ID Q04206
Background	NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a transcription factor that controls the transcription of many genes that are associated with immuno-response, anti-apoptosis, neuroplasticity and memory. There are five NF-κB proteins in mammals: RelA(NF-κB p65), RelB, c-Rel, NF-κB (NF-κB p105), and NF-κB2 (NF-κB p100). They form a variety of homodimers and heterodimers, each of which activates its own distinctive set of genes. P65 has been shown to be involved with DNA binding  Mitogen and stress activated protein kinase phosphorylates NF-κB p65 at serine 276 and controls stem cell factor expression in inflammation.
Synonyms	NF kappa B p65, NFkB p65, Transcription factor p65, Rel A, NFKB3
Reference Data

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