TIE1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 2-5 μg/ml.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Highly pure (> 95%) recombinant Mouse soluble TIE-1 (Ser22-Ala748) derived from Insect cells (Cat.-No AR31061PU)
Specificity	Recognizes Mouse TIE-1 and cross reacts with Human TIE-1 .
Formulation	PBS, pH 7.2 State: Purified State: Liquid purified IgG fraction
Reconstitution Method	Restore in sterile water to a concentration of 0.1-1.0 mg/ml. Centrifuge vial prior to opening.
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Database Link	Entrez Gene 21846 Mouse UniProt ID Q06806
Background	TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis.
Synonyms	TIE, Tie-1
Reference Data

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