Botulinum neurotoxin type A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA (1/10,000). Dot blot.  Western blot.
Reactivity	Clostridium botulinum
Host	Rabbit
Clonality	Polyclonal
Immunogen	Type A Neurotoxin and Complexing Proteins Toxoid.
Specificity	Recognizes C. Botulinum Type A Neurotoxin Complex, neurotoxin or protein isolates.
Formulation	1x PBS, pH 7.2 containing 20% Glycerol State: Purified State: Liquid purified IgG fraction Preservative: None
Concentration	lot specific
Purification	Protein G Sepharose Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Database Link	UniProt ID P10845
Background	Clostridium botulinum neurotoxins are zinc-dependent proteases that block the release of acetylcholine from peripheral cholinergic nerve endings by targeting specific membrane proteins including synaptosomal-associated proteins (SNAP), vesicle-associated membrane proteins (VAMP), and syntaxins. Neurotoxin A is characteristically associated with human botulism and known to target and hydrolyse the 197-Gln-|-Arg-198 bond of SNAP-25.
Synonyms	BoNT/A, Clostridium botulinum Toxin A, Bontoxilysin-A, BOTOX
Reference Data

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