Myosin light chain 3 (MYL3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA. Western Blot.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant human myosin (cardiac) light chain fragment.
Specificity	This antibody reacts to ventricular myosin light chain.
Formulation	Azide Free, 0.05 M Phosphate buffer, 0.1 M NaCl, pH 7.2 State: Aff - Purified State: Lyophilized purified IgG Preservative: None
Reconstitution Method	Restore with 0.05 ml of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
Concentration	lot specific
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	myosin light chain 3
Database Link	Entrez Gene 4634 Human UniProt ID P08590
Background	Human ventricular myosin light chain (MLC-I, Essential Myosin Light Chain Isoform) is a 21 kDa cardiac contractile protein, which is one of component of myosin structure. The protein MLC-I is present in the contractile apparatus and not in cytosol. In severe congestive heart failure (CHF), myofibrils may degenerate and, subsequently, the myofibrillar components may be released into the circulation. The increased blood levels of MLC-I could indicate morphological changes in CHF, myocardial infarction, structural abnormalities in viable myocytes also observed in non-ischaemic CHF, myocardial necrosis.
Synonyms	Myosin light chain 3, Myosin light chain 1, slow-twitch muscle B/ventricular isoform, MLC1SB, Cardiac myosin light chain 1, CMLC1
Note	Quality Control Test Indirect ELISA - to determine titer of the antibody. SDS PAGE - to determine purity of the antibody.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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