HIPPI (IFT57) Mouse Monoclonal Antibody [Clone ID: 1E1]

Specifications

Product Data
Clone Name	1E1
Applications	IHC, IP, WB
Recommend Dilution	Western Blot: 1:1000, Immunoprecipitation, Immunohistochemistry, Immunohistochemistry-Paraffin
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human HIP1r-TALIN Homology Region (57 kDa).
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	intraflagellar transport 57
Database Link	NP_060480 Entrez Gene 303968 RatEntrez Gene 55081 Human UniProt ID Q9NWB7
Background	Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.
Synonyms	ESRRBL1; HIPPI; MHS4R2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Huntington's disease

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