SUCLA2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:1000-1:20000
Reactivity	Human, Mouse, Rat, Xenopus, Zebrafish, Bovine, X. tropicalis
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 138 and 416 of SUCLA2 (Uniprot ID#Q9P2R7)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	50 kDa
Gene Name	succinate-CoA ligase ADP-forming beta subunit
Database Link	NP_003841 Entrez Gene 20916 MouseEntrez Gene 361071 RatEntrez Gene 8803 Human UniProt ID Q9P2R7
Background	Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq]
Synonyms	A-BETA; MTDPS5; SCS-betaA
Note	Seq homology of immunogen across species: Rat (88%), Xenopus laevis (85%), Zebrafish (81%), Bovine (92%), Xenopus tropicalis (83%)
Reference Data
Protein Pathways	Citrate cycle (TCA cycle), Metabolic pathways, Propanoate metabolism

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