GAPDH Mouse Monoclonal Antibody [Clone ID: 1D4]

Specifications

Product Data
Clone Name	1D4
Applications	WB
Recommend Dilution	WB
Reactivity	Human, Mouse, Rat, Monkey, Dog
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified pig GAPDH
Formulation	PBS, pH 7.4 with 0.05% sodium azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	glyceraldehyde-3-phosphate dehydrogenase
Database Link	NP_002037 Entrez Gene 14433 MouseEntrez Gene 24383 RatEntrez Gene 403755 DogEntrez Gene 574353 MonkeyEntrez Gene 2597 Human UniProt ID P04406
Background	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD), an important energy-yielding step in carbohydrate metabolism. Recent evidence suggests that it also is involved in a number of cellular processes such as membrane fusion, phosphotransferase activity, DNA replication and repair, and nuclear RNA export (1). GAPDH has also been implicated in playing a role in different pathologies such as cancer progression, apoptosis, and neuronal diseases such as Alzheimer’s and Huntington’s disease (2). GAPDH is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.
Synonyms	G3PD; GAPD; HEL-S-162eP
Reference Data
Protein Families	ES Cell Differentiation/IPS
Protein Pathways	Alzheimer's disease, Glycolysis / Gluconeogenesis, Metabolic pathways

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