Aconitase 1 (ACO1) Rabbit Polyclonal Antibody
CAT#: TA321448S
Anti-ACO1 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | IHC: 50-200 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region derived from 132-146 amino acids of human aconitase 1, soluble |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | aconitase 1 |
Database Link | |
Background | Aconitase 1; also known as iron regulatory element binding protein 1 (IREB1); is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA; and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA; and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus; IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity; and hence grouped with the aconitase family of enzymes. |
Synonyms | ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Metabolic pathways |
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