RAD50 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: 293T, Hela, K562, NIH/3T3 and RAW264.7 cells IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 325-339 amino acids of Human RAD50 homolog (S. cerevisiae)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	154 kDa
Gene Name	RAD50 double strand break repair protein
Database Link	NP_005723 Entrez Gene 19360 MouseEntrez Gene 64012 RatEntrez Gene 10111 Human UniProt ID Q92878
Background	The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50; a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein; cooperating with its partners; is important for DNA double-strand break repair; cell cycle checkpoint activation; telomere maintenance; and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
Synonyms	hRad50; NBSLD; RAD502
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Homologous recombination, Non-homologous end-joining

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