Apolipoprotein B (APOB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 15-50 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 2158-2177 amino acids of human apolipoprotein B (including Ag(x) antigen)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	apolipoprotein B
Database Link	NP_000375 Entrez Gene 54225 RatEntrez Gene 238055 MouseEntrez Gene 338 Human UniProt ID P04114
Background	This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms; apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single; very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA); resulting in the creation of a stop codon; and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia; normotriglyceridemic hypobetalipoproteinemia; and hypercholesterolemia due to ligand-defective apoB; diseases affecting plasma cholesterol and apoB levels.
Synonyms	FLDB; LDLCQ4
Reference Data
Protein Families	Druggable Genome, Transmembrane

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