DRP1 (DNM1L) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	DNM1L antibody was raised against a 19 amino acid peptide near the center of human DNM1L.
Formulation	DNM1L antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	DNM1L antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 81 kDa; Observed: 80 kDa
Gene Name	dynamin 1-like
Database Link	NP_036192 Entrez Gene 74006 MouseEntrez Gene 10059 Human UniProt ID O00429
Background	The Dynamin-1-like protein (DNM1L) is a member of the dynamin superfamily of GTPases (1). DNM1L mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis (2). Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF) (3).
Synonyms	DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV
Reference Data
Protein Pathways	Endocytosis, Fc gamma R-mediated phagocytosis

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