SETD7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ChIP, IHC, WB
Recommend Dilution	Chromatin Immunoprecipitation (ChIP): 1:10-1:500, Western Blot: 1:500-1:1000, Immunohistochemistry-Paraffin: 1:100, Immunohistochemistry
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Two synthethic peptides corresponding to amino acids 131-145 (GEVNEDGEMTGEKIA) and 336-352 (GYDHSPPGKSGPEAPEW) of human SETD7 were used as immunogen for this antibody.
Formulation	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Whole antisera
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	SET domain containing lysine methyltransferase 7
Database Link	NP_085151 Entrez Gene 73251 MouseEntrez Gene 80854 Human UniProt ID Q8WTS6
Background	Diverse signal transduction pathways impinging on the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. Set7/9 is a histone specific HMTase that methylates histone H3 lysine 4. Set7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. Human Set7/9 is a 336 amino acid protein.
Synonyms	9; KMT7; SET7; SET9
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Lysine degradation

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