Carbonic Anhydrase IX (CA9) Mouse Monoclonal Antibody [Clone ID: 2D3]

Specifications

Product Data
Clone Name	2D3
Applications	CyTOF-ready, ELISA, FC, ICC/IF, IHC, WB
Recommend Dilution	Flow (Intracellular): 1 ug/mL, Immunocytochemistry/ Immunofluorescence, Western Blot: 1:2000, ELISA: 1:10000, Flow Cytometry: 1:200 - 1:400, Immunohistochemistry: 1:10 - 1:500, Immunohistochemistry-Paraffin: 1:200 - 1:1000, CyTOF-ready
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human Carbonic Anhydrase IX expressed in E. coli. [UniProt# Q16790]
Formulation	PBS with 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	IgG purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	50 kDa
Gene Name	carbonic anhydrase 9
Database Link	NP_001207 Entrez Gene 768 Human UniProt ID Q16790
Background	Carbonic Anhydrase IX, also known as CA9, is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. Tissue specificity: Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.
Synonyms	CAIX; MN
Note	This Carbonic Anhydrase IX (2D3) antibody is useful for Western blot, Flow Cytometry, Immunohistochemistry on paraffin-embedded sections and ELISA.
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Nitrogen metabolism

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