Alpha Dystroglycan (DAG1) Mouse Monoclonal Antibody [Clone ID: 43DAG1/8D5]

Specifications

Product Data
Clone Name	43DAG1/8D5
Applications	IHC
Recommend Dilution	1:50-1:200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide containing 15 of the last 16 amino acids at the extreme C-terminus of the human beta-dystroglycan sequence (PKNMTPYRSPPPYVP-PCOOH)
Specificity	Human beta-dystroglycan (43 kD). Also crossreacts strongly with beta-dystroglycan in sections of mouse, rat, rabbit, dog and chicken, hamster and toad muscle. Other animal species not tested.
Formulation	Lyophilized tissue culture supernatant containing sodium azide as a preservative.
Reconstitution Method	The user is required to reconstitute the contents of the vial with the correct volume of sterile distilled water as indicated on the vial label
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	dystroglycan 1
Database Link	Entrez Gene 1605 Human UniProt ID Q14118
Background	Dystrophin associated glycoproteins (DAGs) are involved in the attachment of dystrophin to muscle membranes. The biological significance of this dystrophin/glycoprotein complex is not fully understood, but it appears to form an essential linkage between actin on the inside of the muscle fiber and muscle laminin in the basal lamina which surrounds the fiber. Beta-dystroglycan spans the sarcolemma and it has been suggested that it is the member of the complex which binds directly to dystrophin.
Synonyms	156DAG; A3a; AGRNR; alpha-dystroglycan; beta-dystroglycan; DAG
Reference Data

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