PTEN Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1C3]

CAT#: TA801053BM

PTEN mouse monoclonal antibody,clone 1C3, HRP conjugated

Conjugation: Unconjugated Biotin HRP



  View other "OTI1C3" antibodies (4)

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CNY 3,990.00


货期*
2周

规格
    • 100 ul

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Recombinant protein of human phosphatase and tensin homolog (PTEN), 20 µg
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Transient overexpression lysate of phosphatase and tensin homolog (PTEN)
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Specifications

Product Data
Clone Name OTI1C3
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human PTEN (NP_000305) produced in SF9 Cell.
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol.
Concentration 0.5 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation HRP
Storage Condition Store at -20°C as received.
Predicted Protein Size 47 kDa
Background This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
Synonyms 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Reference Data
Protein Families Druggable Genome, Phosphatase
Protein Pathways Endometrial cancer, Focal adhesion, Glioma, Inositol phosphate metabolism, Melanoma, p53 signaling pathway, Pathways in cancer, Phosphatidylinositol signaling system, Prostate cancer, Small cell lung cancer, Tight junction
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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