Caspase 8 (CASP8) (NM_001228) Human 3' UTR Clone

CAT#: SC212578

3' UTR clone of caspase 8 apoptosis-related cysteine peptidase (CASP8) transcript variant A for miRNA target validation



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CNY 4,845.00


货期*
3周

规格
    • 10 ug

Product images

经常一起买 (2)
Firefly luciferase assay kit, 150 assays
    • 1 kit

CNY 1,520.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00

Specifications

Product Data
Product Name Caspase 8 (CASP8) (NM_001228) Human 3' UTR Clone
Vector pMirTarget
Synonyms ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
ACCN NM_001228
Insert Size 1150 bp
Sequence Data
>SC212578 3’UTR clone of NM_001228
The sequence shown below is from the reference sequence of NM_001228. The complete sequence of this clone may contain minor differences, such as SNPs.
Blue=Stop Codon Red=Cloning site

GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG
TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC
AGAAAAAAACTTGTCTTCCCTTCTGATTGATGGTGCTATTTTGTTTGTTTTGTTTTGTTTTGTTTTTTT
GAGACAGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACCGCAAGCTCCG
CCTCCCGGGTTCAGGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGGGCCCGCCACCA
CACCTGGCTAATTTTTTAAAAATATTTTTAGTAGAGACAGGGTTTCACTGTGTTAGCCAGGGTGGTCTT
GATCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCG
CGCCTGGCCGATGGTACTATTTAGATATAACACTATGTTTATTTACTAATTTTCTAGATTTTCTACTTT
ATTAATTGTTTTGCACTTTTTTATAAGAGCTAAAGTTAAATAGGATATTAACAACAATAACACTGTCTC
CTTTCTCTTATGCTTAAGGCTTTGGGAATGTTTTTAGCTGGTGGCAATAAATACCAGACACGTACAAAA
TCCAGCTATGAATATAGAGGGCTTATGATTCAGATTGTTATCTATCAACTATAAGCCCACTGTTAATAT
TCTATTAACTTTAATTCTCTTTCAAAGCTAAATTCCACACTACCACATTAAAAAAATTAGAAAGTAGCC
ACGTATGGTGGCTCATGTCTATAATCCCAGCACTTTGGGAGGTTGAGGTGGGAGGATTGCTTGAACCCA
AGAGGTCAAGGCTGCAGTGAGCCATGTTCACACCGCTGCACTCAAGCTTGGGTGACAGAACAAGACCCC
GTCTCAAAAAAAATTTTTTTTTTAATAAAACAAAATTTGTTTGAAATCTTTTAAAAATTCAAATGATTT
TTACAAGTTTTAAATAAGCTCTCCCCAAACTTGCTTTATGCCTTCTTATTGCTTTTATGATATATATAT
GCTTGGCTAACTATATTTGCTTTTTGCTAACAATGCTCTGGGGTCTTTTTATGCATTTGCATTTGCTCT
TTCATCTCTGCTTGGATTATTTTAAATCATTAGGAATTAAGTTATCTTTAAAATTTAAGTATCTTTTTT
CAAAAACATTTTTTAATAGAATAAAATATAATTTGATCTTATTAAA
ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA
CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites SgfI-MluI     
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq NM_001228.4
Synonyms ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Locus ID 841
MW 44.3
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