United States
Germany
Japan
United Kingdom
China
Pyruvate Dehydrogenase E2 (DLAT) (NM_001931) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC206640L1V
- LentiORF®
-
Lenti ORF particles, DLAT (Myc-DDK tagged) - Human dihydrolipoamide S-acetyltransferase (DLAT), nuclear gene encoding mitochondrial protein, 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 8,930.00
货期*
详询
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Product Name | Pyruvate Dehydrogenase E2 (DLAT) (NM_001931) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | DLTA; E2; PBC; PDC-E2; PDCE2 |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_001931 |
| ORF Size | 1941 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC206640).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001931.2 |
| RefSeq Size | 3321 bp |
| RefSeq ORF | 1944 bp |
| Locus ID | 1737 |
| Domains | biotin_lipoyl, 2-oxoacid_dh, e3_binding |
| Protein Families | Druggable Genome |
| Protein Pathways | Citrate cycle (TCA cycle), Glycolysis / Gluconeogenesis, Metabolic pathways, Pyruvate metabolism |
| MW | 69 kDa |
| Gene Summary | This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
其它Pyruvate Dehydrogenase E2产品
Customer
Reviews
Loading...
