RUNX1T1 (NM_175636) Human Mass Spec Standard

CAT#: PH300898

RUNX1T1 MS Standard C13 and N15-labeled recombinant protein (NP_783554)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Transient overexpression lysate of runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 2
    • 100 ug

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Specifications

Product Data
Description RUNX1T1 MS Standard C13 and N15-labeled recombinant protein (NP_783554)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC200898
Predicted MW 63.2 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_783554
RefSeq Size 7319
RefSeq ORF 1701
Synonyms AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2
Locus ID 862
Cytogenetics 8q21.3
Summary This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Protein Families Transcription Factors
Protein Pathways Acute myeloid leukemia, Pathways in cancer
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