Interferon alpha 2 (IFNA2) (NM_000605) Human Mass Spec Standard

CAT#: PH321091

IFNA2 MS Standard C13 and N15-labeled recombinant protein (NP_000596)



  View other "Interferon alpha 2" proteins (6)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description IFNA2 MS Standard C13 and N15-labeled recombinant protein (NP_000596)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC221091
Predicted MW 21.4 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000596
RefSeq Size 1142
RefSeq ORF 564
Synonyms IFN-alpha-2; IFN-alphaA; IFNA; IFNA2B; leIF A
Locus ID 3440
Cytogenetics 9p21.3
Summary This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach. [provided by RefSeq, Aug 2020]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Antigen processing and presentation, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Regulation of autophagy, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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