Sm (Smith Antigen) Bovine Protein

Specifications

Product Data
Description	Sm (Smith Antigen) bovine protein, 1 kU
Species	Bovine
Protein Source	Spleen
Concentration	lot specific
Purity	Immobilized human anti-Sm immune globulins. Purification is verified by SDS PAGE. Other antigens (SSA, SSB, RNP, Scl-70, Jo-1) are not detected with ELISA assays.
Buffer	Presentation State: Aff - Purified State: Liquid purified Buffer System: 0.01M Tris, 0.53M Sodium chloride containing 0.02% Sodium azide
Bioactivity	Biological: One unit of activity is the amount of antigen that will generate an absorbance of 1.2 when assayed using standard procedure for enzyme immunoassay. Activity will vary with assay conditions/protocols. Specific: 1000 Units/ml
Preparation	Liquid purified
Applications	Use in standard solid phase immunoassays.
Protein Description	Sm (Smith) Antigen
Storage	Store the protein at -70°C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
Summary	The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30% of patients with SLE. This antibody recognizes cross-reactive epitopes on the B'/B and D polypeptides of Sm. It precipitates the small nuclear RNAs U1, U2, U4, U5, and U6 providing direct evidence that the Sm antigen resides on all these RNA-protein complexes.

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