Apolipoprotein A I / APO AI Human Protein

Specifications

Product Data
Description	Apolipoprotein A I / APO AI human protein, 0.5 mg
Species	Human
Protein Source	Plasma
Predicted MW	28 kDa
Purity	>90%
Buffer	Presentation State: Purified State: Lyophilized purified protein Buffer System: 0.05 M Sodium Chloride, 0.01 M Sodium Carbonate without preservatives or stabilizers
Reconstitution	Restore with 1.0 ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. We recommend that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% Sodium Azide is recommended.
Preparation	Lyophilized purified protein
Applications	Can be used for coating microplates and as a ligand for immunosorbent preparation.
Protein Description	Purified Human Apo A1 prepared by Ultracentrifugation, Delipidation and Gel Filtration.
Note	Caution: Donor material tested and found negative for HBsAg, HIV1, HIV2 and HCV antibodies. As no test can completely guarantee this material to be free of pathogens it should be handled as potentially infectious.
Storage	Store Prior to reconstitution at 2-8°C and After reconstitution store at -20°C. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein.
Stability	Shelf life: one year from date of despatch.
Reference Data
RefSeq	NP_000030
Locus ID	335
Cytogenetics	11q23.3
Synonyms	apo(a); HPALP2
Summary	This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	PPAR signaling pathway

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