CD105 / Endoglin Human Protein

Specifications

Product Data
Species	Human
Expression Host	Insect
Predicted MW	90 kDa
Purity	>95% > 95% (SDS-PAGE and visualized by Silverstain).
Buffer	Presentation State: Purified State: Lyophilized without buffer and stabilizer.
Preparation	Lyophilized without buffer and stabilizer.
Protein Description	Human Endoglin is a disulfide-linked homodimeric protein. Based on N-terminal sequence analysis, the primary structure of recombinant mature Endoglin starts at Glu 26. Endoglin has a calculated monomeric molecular mass of 61 kDa but as a result of glycosylation, migrates at approximately 75-85 kDa under reducing conditions in SDS-PAGE.
Note	Centrifuge vials before opening!
Storage	Store lyophilized sCD105 at -20°C. Reconstituted should be stored in working aliquots at -20°C to -70°C. For long term storage as a dilute solution, a carrier protein (e.g. 0.1% HSA or BSA) should be added to the vial. Avoid repeated freeze-thaw cycles!
Stability	Shelf life: One year from despatch.
Bioactivity	Biological: Measured by its ability to bind with rhTGF-β RII/Fc in a functional ELISA.
Endotoxin	< 0.1 ng per µg of sCD105.
Reference Data
RefSeq	NP_000109
Locus ID	2022
UniProt ID	P17813, Q5T9B9
Cytogenetics	9q34.11
Synonyms	END; HHT1; ORW1
Summary	This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

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