Frizzled 6 (FZD6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 100-300 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 47-60 amino acids of human frizzled family receptor 6
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	frizzled class receptor 6
Database Link	NP_003497 Entrez Gene 14368 MouseEntrez Gene 8323 Human UniProt ID O60353
Background	This gene represents a member of the 'frizzled' gene family; which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide; a cysteine-rich domain in the N-terminal extracellular region; and seven transmembrane domains; but unlike other family members; this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade; thereby inhibiting the processes that trigger oncogenic transformation; cell proliferation; and inhibition of apoptosis. Alternative splicing results in multiple transcript variants; some of which do not encode a protein with a predicted signal peptide.
Synonyms	FZ-6; FZ6; HFZ6; NDNC10
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway

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