Frizzled 6 (FZD6) Rabbit Polyclonal Antibody

CAT#: TA324004S

Anti-FZD6 Rabbit Polyclonal Antibody

Size: 25 ul 100 ul



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CNY 800.00

CNY 1,280.00


货期*
2周

规格
    • 25 ul

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经常一起买 (2)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Transient overexpression lysate of frizzled homolog 6 (Drosophila) (FZD6), transcript variant 1
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Applications IHC
Recommend Dilution IHC: 100-300
Positive control: Human thyroid cancer
Predicted cell location: Cytoplasm
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 47-60 amino acids of human frizzled family receptor 6
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name frizzled class receptor 6
Background This gene represents a member of the 'frizzled' gene family; which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide; a cysteine-rich domain in the N-terminal extracellular region; and seven transmembrane domains; but unlike other family members; this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade; thereby inhibiting the processes that trigger oncogenic transformation; cell proliferation; and inhibition of apoptosis. Alternative splicing results in multiple transcript variants; some of which do not encode a protein with a predicted signal peptide.
Synonyms FZ-6; FZ6; HFZ6; NDNC10
Reference Data
Protein Families Druggable Genome, GPCR, Transmembrane
Protein Pathways Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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