Parathyroid hormone related protein (PTHLH) (107-111) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	ELISA: 1/5000. Immunohistochemistry on Paraffin Sections: 1/100.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic Human PTHrP (107-111) KLH-conjugated
Specificity	This antibody detects PTHrP (aa 107-111).
Formulation	State: Serum State: Lyophilized Serum
Reconstitution Method	Restore in aqua bidest to initial volume.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing.
Gene Name	parathyroid hormone-like hormone
Database Link	Entrez Gene 5744 Human UniProt ID P12272
Background	Parathyroid Hormone (PTH), which is also designated parathyrin, is an 84 amino acid single chain peptide that functions to regulate calcium metabolism by raising blood levels of calcium through various mechanisms. PTH stimulates bone formation to increase bone mass and strength in rats and humans. Within the PTH molecule, the essential activity is associated with the first 34 amino acids at the amino-terminus of the molecule. The gene encoding PTH maps to human chromosome 11p15.3-p15.1. Parathyroid hormone-related protein (PTH-rP) is an autocrine factor that is structurally related to PTH yet, unlike PTH, which is synthesized only by the parathyroid cells, PTH-rP is synthesized by several cell types. PTH-rP regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Isolated from the culture medium of a human lung cancer cell line, PTH-rP produces PTH-like effects that are characterized as humoral hypercalcemia of malignancy.
Synonyms	PTH-rP, Parathyroid hormone related protein, PTHLH, PLP, Parathyroid hormone-like protein
Note	LocusID 5744
Reference Data

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