NF-kB p65 (RELA) pSer468 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA: The antibody (approx. 1:50,000 -1:120,000 diluted) can detect the serine 468 phosphorylated NF-κB p65 peptide coated on ELISA plate at 100ng/well.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from Serine 468 phosphorylated NF-κB p65, conjugated with KLH
Specificity	This antibody is reactive to the synthetic NF-κB -p65 peptide (FTDLASpVDNSE) with Mouse, Human and other species with consensus serine 468 phosphorylated NF-κB -p65 peptide.
Formulation	State: Azide Free State: Lyophilized Ig fraction
Purification	Protein G affinity
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	RELA proto-oncogene, NF-kB subunit
Database Link	Entrez Gene 5970 Human UniProt ID Q04206
Background	NF-κB (nuclear factor kappa-light-chainenhancer of activated B cells) is a transcription factor that controls the transcription of many genes that are associated with immuno-response, antiapoptosis, neuroplasticity and memory. There are five NF-κB proteins in mammals: RelA(NF-κB-p65), RelB, c-Rel, NF-κB (NF-κB-p105), and NF-κB2 (NF- κB-p100). They form a variety of homodimers and heterodimers, each of which activates its own distinctive set of genes. P65 has been shown to be involved with DNA binding. The phosphorylation of p65 at Ser468 is inducible by TNF. The phosphorylation mediates p65 ubiquitination and the termination of related gene expression.
Synonyms	NF kappa B p65, NFkB p65, Transcription factor p65, Rel A, NFKB3
Reference Data

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