BubR1 (BUB1B) Rabbit Polyclonal Antibody

CAT#: AP55089SU-N

BubR1 (BUB1B) rabbit polyclonal antibody, Serum



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CNY 6,600.00


货期*
8周

规格
    • 200 ul

Product images

Specifications

Product Data
Applications ELISA, IHC, WB
Recommend Dilution

ELISA.
Western Blot: 1/200-1/2000.
Immunohistochemistry: 1/50-1/500.

Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide derived from N-terminal domain of Human BUB1B
Specificity Reacts with Human 115 kDa protein.
Reacts with cleaved protein and cross reacts with Mouse BUB1 protein.
Formulation State: Serum
State: Lyophilized powder
Preservative: None
Reconstitution Method Restore in distilled water.
Conjugation Unconjugated
Storage Condition

Prior to reconstitution store the antibody at -20°C.
Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Gene Name BUB1 mitotic checkpoint serine/threonine kinase B
Background Metaphase checkpoint controls sense abnormalities in chromosome alignment during mitosis and prevent progression to anaphase until proper alignment has been attained. A number of proteins, including Mitotic arrest deficiency protein 2 (MAD2), Budding uninhibited benzimidazole 1 (BUB1) and Budding uninhibited benzimidazole receptor 1 (BUBR1), have been implicated in the metaphase checkpoint control in mammalian cells. BUB1 and BUBR1 both localize to kinetochores during mitosis, suggesting that they play a role in delaying anaphase until all chromosomes achieve correct, bipolar attachment to the spindle. BUB1 and BUBR1 respond differently to spindle dynamics; they are part of a common complex during mitosis and BUB1 and BUBR1 may integrate different 'spindle assembly signals' into a single signal which can then be interpreted by downstream cell cycle regulators.
Synonyms Protein SSK1, BUBR1, MAD3L, BUB1 beta
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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