NGAL (LCN2) Rabbit Polyclonal Antibody

CAT#: TA322583S

Anti-LCN2 Rabbit Polyclonal Antibody

Size: 25 ul 100 ul



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CNY 800.00

CNY 1,280.00


货期*
2周

规格
    • 25 ul

Product images

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Transient overexpression lysate of lipocalin 2 (LCN2)
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Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 1000-5000
WB positive control: Human liver cancer tissue
IHC: 50-200
Positive control: Human breast cancer
Predicted cell location: Cytoplasm
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide peptide corresponding to a region derived from 60-73 amino acids of human lipocalin 2
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 23 kDa
Gene Name lipocalin 2
Background Iron-trafficking protein involved in multiple processes such as apoptosis; innate immunity and renal development. Binds iron through association with 2;5-dihydroxybenzoic acid (2;5-DHBA); a siderophore that shares structural similarities with bacterial enterobactin; and delivers or removes iron from the cell; depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor; leading to release of iron and subsequent increase of intracellular iron concentration. In contrast; association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore; iron chelation and iron transfer to the extracellular medium; thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis; while iron-free form decreases intracellular iron levels; inducing expression of the proapoptotic protein BCL2L11/BIM; resulting in apoptosis. Involved in innate immunity; possibly by sequestrating iron; leading to limit bacterial growth.
Synonyms 24p3; MSFI; NGAL
Reference Data
Protein Families Secreted Protein
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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