DECTIN 2 (CLEC6A) Mouse Monoclonal Antibody [Clone ID: 3D1]

Specifications

Product Data
Clone Name	3D1
Applications	CyTOF-ready, FC, IHC, WB
Recommend Dilution	Immunohistochemistry-Paraffin: 1:200, Immunohistochemistry: 1:200, Flow (Cell Surface), CyTOF-ready, Western Blot: 2 - 5ug/mL, Flow Cytometry: 0.5 ug/5x10^5 cells
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A portion of amino acids 75-139 of human Dectin-2 was used as the immunogen for the antibody. 90-106
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	C-type lectin domain family 6 member A
Database Link	NP_001007034 Entrez Gene 93978 Human UniProt ID Q6EIG7
Background	Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages and inflammatory monocytes. It is a type II membrane receptor, with a short cytoplasmic tail, and a C-terminal C-type lectin domain. Dectin-2 is a receptor with specificity for high mannose structures and mediates cytokine production from DC and other antigen presenting cells. Though, Dectin-2 has no obvious signaling motifs attached to CP tail, reports indicate that Dectin-2 employs FcR 7; for internalization and to activate NF-kB pathway for cytokine production. Though it shares only 20-25% of homology with Dectin-1, it functions similarly as pattern recognition receptor (PRR) for fungal infections, to activate both innate (Syk-CARD9 innate signaling pathway) and adaptive immune responses (by activation of DC) to fungal infections. Thus Dectin-2 is a connector molecule of both innate and adaptive immunity functioning at DC level.
Synonyms	CLEC4N; CLECSF10
Reference Data
Protein Families	Transmembrane

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