Wnk1 (NM_198703) Mouse Untagged Clone
CAT#: MC225299
Wnk1 (untagged) - Mouse WNK lysine deficient protein kinase 1 (Wnk1), transcript variant 1, (10ug)
CNY 38,190.00
货期*
12周
规格
Product images
经常一起买 (3)
Specifications
Product Data | |
Type | Mouse Untagged Clone |
Tag | Tag Free |
Synonyms | 6430573H23Rik; EG406236; Hsn2; mKIAA0344; Prkwnk1 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MC225299 representing NM_198703
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGTCTGACGGTGCCGCCGAGAAGCAAAGCGGCACTCCGGGCTTCCTTACGCCTCCGGCGCCCGTCCCCA AGAATGGCTCAAGCTCCGATTCTTCCGTGGGCGAGAAACTGGGGGCTACGGTCGCCGACTCGGGAGTTGG CAGGACGGAGGAATATCGGCGCCGCCGGCACACTATGGACAAGGACAGTCGTGGGGCGGCCGCCACCACC ACCCCCACGGAGCACCGATTCTTCCGCCGAAGCGTCATCTGCGACTCCAATGCCACCGCGTTGGAGCTGC CGGGCCTCCCTCTCTCTATCCCGCAACCTAGTGTACCTGCAGTGGTGCCCCAGAGTGCTCCACCCGAACC TCACAGAGAGGAAACTTTGACCGCCACCGTTGCTTCCCAGGTGTCTCAGCAACCCTCGGCTGCTGCCTCC CCTGGGGAACAAGCCGTTGTAGGCTCGGCCACCACGACCGTCCCCAGCAGTACCAGCAAAGACCGCCCGG TGTCCCAGCCCAGCCTCGTGGGGAGCAAAGAGGAGCCACCGCCGTCCAGAAGTGGAAGTGGCAGTGGTGG CGCCAGCGCCAAAGAGGCGCAGGAGGATAGGAGCCAGCAACAGGATGATATCGAAGAGCTGGAGACCAAG GCAGTGGGAATGTCCAATGACGGTCGCTTTCTCAAATTTGACATCGAAATCGGCAGAGGCTCCTTTAAGA CAGTCTACAAAGGTCTGGACACCGAAACCACTGTGGAAGTCGCCTGGTGTGAATTGCAGGATCGAAAGTT AACAAAATCTGAAAGGCAGAGATTCAAAGAAGAGGCTGAAATGTTAAAGGGTCTTCAACATCCCAACATT GTTCGATTCTATGATTCCTGGGAATCCACAGTAAAAGGGAAAAAATGCATTGTTTTAGTGACTGAACTAA TGACATCTGGAACACTTAAGACGTACTTAAAAAGGTTTAAAGTGATGAAAATCAAAGTTTTAAGAAGCTG GTGTCGGCAAATCCTTAAAGGGCTTCAGTTTCTCCACACACGAACTCCACCAATTATTCACCGGGATCTT AAATGTGACAACATCTTTATCACTGGTCCTACTGGCTCAGTCAAGATCGGAGACCTTGGTCTGGCAACTC TAAAGCGGGCTTCTTTTGCCAAGAGTGTGATAGGTACCCCAGAGTTTATGGCTCCTGAGATGTATGAGGA GAAATATGATGAATCCGTTGATGTTTATGCTTTTGGGATGTGCATGCTTGAGATGGCTACATCTGAATAT CCATACTCAGAATGCCAAAATGCTGCGCAGATCTACCGTCGAGTGACCAGTGGAGTGAAGCCAGCCAGTT TTGACAAAGTAGCAATTCCTGAAGTAAAAGAAATTATTGAAGGATGTATCCGACAAAACAAAGATGAAAG ATATTCCATCAAAGACCTTTTGAACCATGCCTTTTTCCAGGAGGAAACAGGGGTACGGGTAGAATTAGCA GAAGAAGATGATGGAGAAAAGATAGCTATTAAATTATGGCTGCGTATTGAAGATATTAAGAAATTAAAGG GAAAATACAAAGACAATGAAGCTATTGAGTTTTCCTTTGACTTGGAGAGGGATGTACCAGAAGATGTTGC TCAAGAAATGGTTGAGTCTGGTTATGTCTGTGAAGGTGATCACAAGACCATGGCTAAAGCTATCAAAGAT AGGGTGTCCTTAATTAAGAGAAAACGAGAGCAGCGGCAGTTGGTTCGAGAAGAGCAAGAAAAAAGAAAAC AAGAAGAGAGCAGTTTCAAACAGCAGAATGAACAACAAGCAAGCGTTTCCCAGGCAGGAATCCAGCAGCT CTCTGCTGCTAGCACTGGCATACCCACTGCTCCTGCCACCTCTGCTTCAGTTTCTACACAGGTAGAACCT GAAGAACCTGAGGCAGATCAACATCAACAGCTGCAATATCAGCAACCTAGTATATCTGTGTTGTCTGATG GAACCATTGATAGTGGTCAAGGATCATCCGTATTCACAGAATCCAGAGTGAGCAGCCAACAGACTGTTTC CTATGGTTCCCAACATGAGCAGGCACATTCTACTGGCACAGCACCAGGACATACAGTTTCTAGTATCCAA GCACAATCTCAGCCCCATGGGGTGTATCCACCCTCAAGTATGGCACAGGGGCAGAACCAGGGCCAGCCAT CAAGTAGTTTGGCTGGGGTTCTATCTTCACAACCTATCCAACATCCTCAGCAGCAGGGAATACAGCCAAC TGTTCCTTCTCAACAGGCAGTACAGTATTCACTTCCACAAGCAGCATCTTCCAGTGAAGGTACTACTGCA CAGCCAGTGAGTCAGCCTCAAGTGTCAGCTGGAACACAGCTTCCAGTTTCCCAGACAGTAGCAACTGTCC AAGGTGAACCTCACATCCCAGTTTCAACACAACCCTCAGTTGTTCCAGTCCACTCTGGTGCTCATTTCCT TCCTATGGGACAGCCAATCCCTACTTCTTTACTCCCACAGTATCCTGTCTCTCAAATTCCCATATCGACT CCTCATGTGTCCACGGCGCAGACAGGTTTCTCATCCGTTCCTATAACAATGGCTGCTGGCATTAACCAGC CTCTGCTCACCTTGGCTTCATCTGCTACAGCATCTTCAATCCCAGGGGGATCACCTGTAGTTCCTAATCA GCTTCCAACTCTTCTGCAGCCTGTGAATCAGCTGCAGAGTCAGGTTCACCCACAGCTTCTACAGCCAACA ACAGTTCAGTCCATAGGAATACCAGCTAACCTTGGACAAGCTGCTGAGGGTCCACTTCCCTCTGGAGATG TTTTGTACCAGGGCTTCCCATCTCGACTGCCACCACAATACCCAGGAGATTCAAATATTGCTCCCTCTTC CAACGTGGCTTCTGTTTGCATCCATTCTACAGTCCTAGCCCCTCCTTCTATGCCGACAGAAGCATTGGCC ACCCAAGGTTACTTTCCTACAGTAGTGCAGCCTTATGTGGAATCAACTCCTTTGGTTCCTATGGGCAGTG TAGGAGGCCAGGTTCAAGTGTCCCAACCAGCAGTGAGTTTAACGCAACAACCCCCAACTACATCCTCCCA GCAAGCAGTTCTGGAGAGTACTCAGGGAGTCTCTCAGGCTGCTCCTCCAGAACAAACTCCAATAACACAG TCACAACCTACTCAGCCTGTTCCATTGGTTACCTCTGCAGACAGTGCACATTCAGACGTTGCTTCTGGTA TGAGTGATGGCAATGAGAATGCTCCATCATCCAGCGGGAGGCATGAAGGGAGGACAACAAAACGGCATTA TAGAAAATCCGTAAGAAGTCGCTCTCGGCATGAAAAGACTTCTCGCCCAAAACTGAGGATTTTAAATGTT TCAAATAAAGGAGACCGAGTAGTAGAATGTCAATTAGAGACTCATAATCGGAAGATGGTTACATTTAAAT TTGACCTAGATGGTGACAACCCTGAAGAGATAGCAACAATTATGGTGAACAATGACTTTATTCTAGCAAT AGAGAGAGAGTCTTTTGTGGCTCAAGTGCGGGAAATTATTGAAAAGGCTGATGAAATGTTAAGTGAGGAT GTCAGTGTGGAGCCTGAGGGTGACCAGGGATTGGAGAGTCTGCAAGGAAAGGATGACTATGGCTTCCCAG GTTCTCAGAAATTAGAAGGAGAGTTCAAGCAACCAATTGCTGTATCTTCCATGCCACAACAAATAGGTGT TCCTACCAGTTCTTTAACGCAAGTTGTTCATTCTGCTGGAAGACGGTTTATAGTGAGTCCTGTACCTGAA AGTAGGTTACGAGAATCAAAAGTTTTCACCAGTGACATATCAGATCCAGTTGTGGCCTCTACATCTCAGG CCCCTGGAATGAACTTATCTCACTCTGCTTCATCCCTCAGTCTCCAGCAGGCTTTTTCTGAACTGAAACA TGGTCAGATGACTGAAGGACCCAATACAGCACCTCCAAATTTTAATCACATGGCGGGACCAACATTTTCT CCCTTTTTGGCTAGCATTGCTGGTGTCCAAACTGTAGCAGCATCCACACCGTCAGTATCAGTCCCTATAA CAAGCAGTCCTCTTAATGACATTTCCACATCAGTGATGCAGTCTGAGACTGCACTGCCCACTGAAAAAGG CATCGTGGGAGTTACCACTACCAGCACAGGTGTGGTAGCTTCAGGTGGTCTCACCACAATGTCTGTGTCT GAGTCACCAACATCTTCCAGTGCGGTTTCAAGTTCTACAGTACCTGCAGTTGTCACTGTGTCCACACCAT CCCAGCCAGTTCAGGCTTCCACATCTGGGAGCATTGCTTCAAGTACAGGCAGTTTTCCTCCTGGAACATT TTCTACAACTACAGCTACTACAATGGGTAGTGTGGTGGCCCCAGATGCTAAGCCTCCAACTGTATTATTG CAACAGGTAGCAAGCAATACTGCTGGGGTTGCCATAGTGACATCAGTCTCTACCACCACTCCATTCCCAG GCATGGCTTCACAGCCATCCCTTCCACTTAGTAGCAGCACCTCTGCTCCTACTCTAGCTGAAACAATGGT GGTTAGTGCACACTCACTAGACAAGGCATCTCACAGTAGTACAGCAGGATTGGGTTTGTCCTTTTGTGCG CCATCCTCTTCCTCCTCCTCTGGAACAGCTGTGTCTACTTCTGTTTCTCAGCCTGGTATGGTTCATCCTT TGGTCATCTCATCAGCTGTAGTTTCTACACCTGGCCTCCCCCAACCAGTAGTACCTACTTCTACACCTTT ATTACCCCAAGTACCTAATATCCCACCCTTGGTACAACCTGTTGTTAATGTGCCTGCTGTACAGCAAACA CTCATTCACAGTCAGCCTCAACCAGCTCTGCTTCCCAACCAGCCTCACACACACTGTCCTGAAATGGATG CTGATACCCAATCCAAAGCTCCTGGGATTGATGATATAAAGACTCTGGAGGAAAAGCTGAGATCTCTCTT TAGTGAACACAGCTCATCTGGAACTCAGCATGCTTCTGTCTCCCTAGAGACACCTTTAGTAGTAGAGACG ACTGTCACACCGGGCATCACTACCACTGCTGTAGCACCAAGTAAACTCATGACTTCCACTACAAGTACTT GCTTACCACCAACCAGTTTACCATTAGGAGCAGCTGGCATGCCAGTTATGCCAGTAGGCACACCTGGGCA GGTTTCTACCCCAGGCACACACGCTTCAGCCCCAGTCGGCACTGCAACAGGAGTAAAACCTGGAACAACT CCCCCAAAGCCAACTAAGACTGTGGTGCCACCAGTGGGTACTGAACTTTCAGCCGGTACTGTACCCTGTG AGCAGCTGCCACCTTTTCCTGGACCTTCTCTAATTCAGTCCCAGCAACCACTAGAAGATCTTGATGCTCA GTTGAGAAGAACACTTAGTCCAGAGACTATTACAGTGGCACCTGCAGTTGGTCCTTTGTCTACGATGTCT TCAACAACAGTTACAGAAGCAGGGACTCGGCTTCAAAAGGATGGCACAGAAGGTCATGTCACAGCAACTA GTTCAGGAGCTGGTGTTGTTAAGATGGGGCGATTTCAGGTTTCAGTTACAATGGATGATGCCCAGAAAGA ACGTAAAAATAGGTCAGAAGATACAAAGTCGGTTCATTTTGAATCTAGCACATCAGAGTCATCAGTTCTT TCAAGTAGTAGTCCAGAGAGTACCCTGGTAAAGCCAGAGCCTAATGGAATTAGTATTTCTGGCATCTCCT TAGATGTCCCAGACAGCACCCACAAAGCACCTACCCCAGAAGCAAAGTCAGATGCAGGACAGCCTACCAA GGTGGGACGTTTTCAGGTGACAACTACAGCCAACAAAGTGGGTCGTTTCTCTGTTTCAAGAACTGAGGAC AAGGTCACAGAGCTCAAAAAAGAGGGACCAGTGACCTCTCCTCCTTTCAGAGATTCAGAACAAACTGTTA TTCCTGCTGTGATACCAAAGAAGGAGAAGCCTGAGCTGGCAGAACCTTCCCATTTGAATGGGCCATCTTC AGACCTGGAGGCTGCCTTTCTAAGTAGGGGTACAGAGGATGGCTCAGGTAGTCCACACTCTCCCCCTCAC CTGTGTTCAAAGAGCCTTCCCGTCCAGAATCTAAGTCAAAGCCTTAGTAATTCATTCAACTCCTCATACA TGAGTAGTGACAATGAGTCCGACATTGAAGATGAAGACTTAAGGTTAGAACTACGACGACTACGAGAAAA ACATCTTAAAGAGATTCAGGACCTGCAGAGTCGCCAGAAGCATGAAATTGAATCTTTGTATACTAAACTG GGCAAGGTTCCCCCTGCTGTCATTATTCCCCCAGCTGCTCCTCTGTCGGGGAGAAGAAGGAGACCCACTA AAAGCAAAGGCAGCAAGTCTAGTCGCAGCAGCTCATTGGGCAATAAAAGCCCACAGCTTTCAGGCAACCT GTCTGGTCAGAGTGGAACTTCAGTCTTACACCCCCAACAGACCCTCCATCCCGCAGGAAACACCCCCGAG ACTGGGCACAACCAGCTGTTACAGCCTCTTAAGCCATCTCCCTCCAGTGACAACCTCTATTCAGCCTTTA CCAGTGATGGTGCCATTTCAGTACCAAGCCTTTCTGCTCCAGGTCAAGGGACCAGCAGCACAAATACCGT TGGAGGAACAGTGAGTAGCCAGGCTGCCCAGGCTCAGCCTCCTGCTATGACTTCCAGTAGGAAGGGCACA TTCACAGATGACCTGCACAAGTTAGTAGACAACTGGGCCCGAGATGCCATGAATCTTTCAGGCAGGAGAG GCAGCAAAGGACACATGAATTATGAGGGCCCTGGAATGGCAAGGAAGTTCTCTGCTCCTGGGCAGCTGTG TGTTCCCATGACCTCAAACCTGGGTGGCTCTACCCCCATCTCTGCAGCATCTGCTACCTCTCTAGGTCAC TTCACCAAATCCATGTGTCCCCCACAGCAGTATGGTTTTCCACCTGCCCCATTTGGCACTCAGTGGAGTG GAACAGGTGGTCCAGCACCGCAGCCACTTGGCCAGTTCCAACCTGTAGGAACAGCATCCTTGCAAAATTT CAACATCAGCAATTTGCAGAAGTCCATCAGCAACCCCCCAGGTTCCAATCTACGGACCACCTAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
Restriction Sites | SgfI-MluI |
ACCN | NM_198703 |
Insert Size | 7134 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
Reference Data | |
RefSeq | NM_198703.3, NP_941992.2 |
RefSeq Size | 10575 bp |
RefSeq ORF | 7134 bp |
Locus ID | 232341 |
UniProt ID | P83741 |
Gene Summary | Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (PubMed:21317537, PubMed:23542070).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame compared to variant 5. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 5. |
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