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Syvn1 (NM_028769) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209408L3V
- LentiORF®
-
Lenti ORF particles, Syvn1 (Myc-DDK-tagged) - Mouse synovial apoptosis inhibitor 1, synoviolin (Syvn1), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 10,830.00
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Specifications
| Product Data | |
| Product Name | Syvn1 (NM_028769) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 1200010C09Rik; AW211966; C85322; D530017H19Rik; Hrd1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_028769 |
| ORF Size | 1839 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209408).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_028769.4, NP_083045.3 |
| RefSeq Size | 3470 bp |
| RefSeq ORF | 1839 bp |
| Locus ID | 74126 |
| Gene Summary | Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12975321, PubMed:15611074). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12975321, PubMed:15611074). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Required for embryogenesis (PubMed:15611074). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (PubMed:21911472).[UniProtKB/Swiss-Prot Function] |
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