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Copb1 (NM_033370) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211294L3V
- LentiORF®
-
Lenti ORF particles, Copb1 (Myc-DDK-tagged) - Mouse coatomer protein complex, subunit beta 1 (Copb1), 200ul, >10^7 TU/mL
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CNY 14,630.00
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Specifications
| Product Data | |
| Product Name | Copb1 (NM_033370) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2610019B04Rik |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_033370 |
| ORF Size | 2859 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211294).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_033370.3, NP_203534.1 |
| RefSeq Size | 3315 bp |
| RefSeq ORF | 2862 bp |
| Locus ID | 70349 |
| Gene Summary | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1 (By similarity). Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins in cortical neurons. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis.[UniProtKB/Swiss-Prot Function] |
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